Addiction 2021.4
12-21-21, 10:41 AM
Should Be More Popular
Join Date: Dec 2007
Location: Malvern, PA (20 miles West of Philly)
Posts: 43,643
Bikes: 1986 Alpine (steel road bike), 2009 Ti Habenero, 2013 Specialized Roubaix
Liked 9,572 Times
in
4,426 Posts
Understood. There are two other hospitals nearby and both of them are closing (one on 12/31 and one on 1/31), so my local hospital may be overwhelmed. I think I am still on a stupid stand-by list to work the floors if they get desperate, my hope is it does not come to that and that our patients who are vaccinated (most of them) won't get very sick.
12-21-21, 10:47 AM
Senior Member
Join Date: Jan 2010
Location: TC, MN
Posts: 39,521
Bikes: R3 Disc, Haanjo
Liked 9,462 Times
in
4,673 Posts
Rolled out on a short ride and it started to rain. Decided to cut it short, got back a half hour later, wiped down the bike and it stopped raining. **** you, rain.
Likes For WhyFi:
12-21-21, 10:52 AM
Fat n slow
Join Date: Oct 2013
Location: Saratoga, NY
Posts: 4,327
Bikes: Cervelo R3, Giant Revolt
Liked 2,113 Times
in
987 Posts
There are some hospitals around here with 400 open nursing positions they can’t fill.
12-21-21, 10:52 AM
Fat n slow
Join Date: Oct 2013
Location: Saratoga, NY
Posts: 4,327
Bikes: Cervelo R3, Giant Revolt
Liked 2,113 Times
in
987 Posts
12-21-21, 11:12 AM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
From what I'm hearing, in places like Rhode Island, the system already IS overwhelmed, and that's BEFORE the full weight of Omichron falls. But again, the hospitalized are primarily unvaccinated. This has become an epidemic of the unvaccinated minority, and for the rest of us it's a continuing annoyance more than a constant threat.
__________________
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
12-21-21, 11:24 AM
Administrator
Thread Starter
Join Date: Apr 2005
Location: Hudson Valley, NY
Posts: 33,394
Bikes: Merlin Cyrene '04; Bridgestone RB-1 '92
Liked 7,205 Times
in
3,723 Posts
OMG Civilization doesn't have a chance if so. 
__________________
See, this is why we can't have nice things. - - smarkinson
Where else but the internet can a bunch of cyclists go and be the tough guy? - - jdon
12-21-21, 11:29 AM
dot dash
Join Date: Jun 2015
Location: Land of Pleasant Living
Posts: 12,577
Bikes: Shmikes
Liked 6,177 Times
in
3,324 Posts
12-21-21, 11:31 AM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
Think of it this way: when you're vaccinated, or infected, your body generates a wide range of antibodies. It does this by having a large pool of B-cells that produce a wide, wide range of different antibody specificities. The cells that produce antibodies that bind to the new pathogen get turned on, not only to reproduce and expand their numbers, but also to undergo their own evolution, in which cells that produce new versions of the original antibodies that bind better are stimulated to reproduce and expand. This leads to your cells producing a whole bunch of antibodies that bind to different places on the virus, so that even if you encounter a new version of the virus that some antibodies don't bind to, there will still be ones that do, and the cells that produce those will expand. This is a POLYclonal response - MANY different antibodies, and also numerous different versions of the original antibodies that kinda/sorta bound, but whose binding has been enhanced by mutation and testing, mutation and testing, mutation and testing. This is why each successive round of immunization increases the efficacy - it stimulates further expansion, mutation and testing.
A monoclonal antibody is made by isolating individual antibody producing cells, finding the one 'best' antibody, decoding the genes to make it, and then using them to make kilograms of that ONE antibody. Hence MONOclonal.
BUT, in addition to the antibody producing cells, the whole immune system is primed to attack the virus and any cells infected with it, so that the infection gets snuffed out as quickly as possible. Each boost refines and broadens the response, so it's not just antibodies, it's also killer T-cells.
Sorry if this is longwinded, but it's why the vaccine, and boosting is so important - it gives the immune system a leg up, so that it's as strong against the virus as if you had been fighting the infection for a week or more already before it even sees the virus. And the immune cells that produce antiviral antibodies, or know how to kill virally infected cells produce 'memory cells' that hang around for years, so that if you ever see that pathogen again, your immune system says, "Oh, yeah! I've seen this! I need these cells to wake up and get to work!", rather than having to come up with a response from baseline again.
__________________
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
12-21-21, 11:33 AM
Senior Member
Join Date: Jan 2010
Location: TC, MN
Posts: 39,521
Bikes: R3 Disc, Haanjo
Liked 9,462 Times
in
4,673 Posts
12-21-21, 11:35 AM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
12-21-21, 11:35 AM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
Likes For genejockey:
12-21-21, 11:40 AM
Mostly Harmless
Join Date: Jul 2008
Location: At Large
Posts: 57,073
Bikes: Have two wheels
Liked 4,945 Times
in
2,650 Posts
12-21-21, 11:46 AM
he said member
Join Date: Sep 2008
Location: is everything
Posts: 13,802
Bikes: yes please
Liked 1,951 Times
in
1,207 Posts
It's like you don't even know me...
What I HAVE been doing is, I took the Canyon off the trainer and put it in with the others so I can see how much space they take up, and amazingly it's still only a 7' x 7' x7' cube. But the Litespeed will be down to the bare frame next week anyhow while I clean all the bits. That reminds me I need to order the decals from Litespeed......
Done. Wonders of modern society. Now I just need the red Scotchbrite pads, and some acetone.
What I HAVE been doing is, I took the Canyon off the trainer and put it in with the others so I can see how much space they take up, and amazingly it's still only a 7' x 7' x7' cube. But the Litespeed will be down to the bare frame next week anyhow while I clean all the bits. That reminds me I need to order the decals from Litespeed......
Done. Wonders of modern society. Now I just need the red Scotchbrite pads, and some acetone.
Likes For ls01:
12-21-21, 11:49 AM
Should Be More Popular
Join Date: Dec 2007
Location: Malvern, PA (20 miles West of Philly)
Posts: 43,643
Bikes: 1986 Alpine (steel road bike), 2009 Ti Habenero, 2013 Specialized Roubaix
Liked 9,572 Times
in
4,426 Posts
Kinda/sorta.
Think of it this way: when you're vaccinated, or infected, your body generates a wide range of antibodies. It does this by having a large pool of B-cells that produce a wide, wide range of different antibody specificities. The cells that produce antibodies that bind to the new pathogen get turned on, not only to reproduce and expand their numbers, but also to undergo their own evolution, in which cells that produce new versions of the original antibodies that bind better are stimulated to reproduce and expand. This leads to your cells producing a whole bunch of antibodies that bind to different places on the virus, so that even if you encounter a new version of the virus that some antibodies don't bind to, there will still be ones that do, and the cells that produce those will expand. This is a POLYclonal response - MANY different antibodies, and also numerous different versions of the original antibodies that kinda/sorta bound, but whose binding has been enhanced by mutation and testing, mutation and testing, mutation and testing. This is why each successive round of immunization increases the efficacy - it stimulates further expansion, mutation and testing.
A monoclonal antibody is made by isolating individual antibody producing cells, finding the one 'best' antibody, decoding the genes to make it, and then using them to make kilograms of that ONE antibody. Hence MONOclonal.
BUT, in addition to the antibody producing cells, the whole immune system is primed to attack the virus and any cells infected with it, so that the infection gets snuffed out as quickly as possible. Each boost refines and broadens the response, so it's not just antibodies, it's also killer T-cells.
Sorry if this is longwinded, but it's why the vaccine, and boosting is so important - it gives the immune system a leg up, so that it's as strong against the virus as if you had been fighting the infection for a week or more already before it even sees the virus. And the immune cells that produce antiviral antibodies, or know how to kill virally infected cells produce 'memory cells' that hang around for years, so that if you ever see that pathogen again, your immune system says, "Oh, yeah! I've seen this! I need these cells to wake up and get to work!", rather than having to come up with a response from baseline again.
Think of it this way: when you're vaccinated, or infected, your body generates a wide range of antibodies. It does this by having a large pool of B-cells that produce a wide, wide range of different antibody specificities. The cells that produce antibodies that bind to the new pathogen get turned on, not only to reproduce and expand their numbers, but also to undergo their own evolution, in which cells that produce new versions of the original antibodies that bind better are stimulated to reproduce and expand. This leads to your cells producing a whole bunch of antibodies that bind to different places on the virus, so that even if you encounter a new version of the virus that some antibodies don't bind to, there will still be ones that do, and the cells that produce those will expand. This is a POLYclonal response - MANY different antibodies, and also numerous different versions of the original antibodies that kinda/sorta bound, but whose binding has been enhanced by mutation and testing, mutation and testing, mutation and testing. This is why each successive round of immunization increases the efficacy - it stimulates further expansion, mutation and testing.
A monoclonal antibody is made by isolating individual antibody producing cells, finding the one 'best' antibody, decoding the genes to make it, and then using them to make kilograms of that ONE antibody. Hence MONOclonal.
BUT, in addition to the antibody producing cells, the whole immune system is primed to attack the virus and any cells infected with it, so that the infection gets snuffed out as quickly as possible. Each boost refines and broadens the response, so it's not just antibodies, it's also killer T-cells.
Sorry if this is longwinded, but it's why the vaccine, and boosting is so important - it gives the immune system a leg up, so that it's as strong against the virus as if you had been fighting the infection for a week or more already before it even sees the virus. And the immune cells that produce antiviral antibodies, or know how to kill virally infected cells produce 'memory cells' that hang around for years, so that if you ever see that pathogen again, your immune system says, "Oh, yeah! I've seen this! I need these cells to wake up and get to work!", rather than having to come up with a response from baseline again.
Epitope.
12-21-21, 11:52 AM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
To be fair, I have been thinking about selling the Lotus Classique. It's a nice bike, but as a Sport Tourer, it doesn't really fit so well into the stable, and unlike the others I don't find myself wanting to ride it. There's not a thing wrong with it - it was probably in the best condition when acquired, and it's in even better shape now - but it just doesn't make me want to ride it. It just needs a replacement for one of the black wraps on the downtube, and it will be done.
__________________
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
12-21-21, 11:55 AM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
12-21-21, 11:57 AM
Should Be More Popular
Join Date: Dec 2007
Location: Malvern, PA (20 miles West of Philly)
Posts: 43,643
Bikes: 1986 Alpine (steel road bike), 2009 Ti Habenero, 2013 Specialized Roubaix
Liked 9,572 Times
in
4,426 Posts
Likes For datlas:
12-21-21, 11:57 AM
he said member
Join Date: Sep 2008
Location: is everything
Posts: 13,802
Bikes: yes please
Liked 1,951 Times
in
1,207 Posts
Likes For ls01:
12-21-21, 12:29 PM
Administrator
Thread Starter
Join Date: Apr 2005
Location: Hudson Valley, NY
Posts: 33,394
Bikes: Merlin Cyrene '04; Bridgestone RB-1 '92
Liked 7,205 Times
in
3,723 Posts
Well ... Ti is fly ... but steel is real. But, yeah, the aluminum ones and carbon ones can now go in the garbage.
__________________
See, this is why we can't have nice things. - - smarkinson
Where else but the internet can a bunch of cyclists go and be the tough guy? - - jdon
12-21-21, 12:35 PM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
So if steel is "gas pipe" and aluminum is "beer can" and carbon fiber is "plastic", what's the slang for Ti?
__________________
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
12-21-21, 12:37 PM
dot dash
Join Date: Jun 2015
Location: Land of Pleasant Living
Posts: 12,577
Bikes: Shmikes
Liked 6,177 Times
in
3,324 Posts
12-21-21, 12:41 PM
dot dash
Join Date: Jun 2015
Location: Land of Pleasant Living
Posts: 12,577
Bikes: Shmikes
Liked 6,177 Times
in
3,324 Posts
Likes For MoAlpha:
12-21-21, 12:44 PM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
Was this purchase a mistake? Am I gonna be mistaken for a dentist? I mean, I work in healthcare, but at the other end of the drug development pipeline. My job is tossing things into one end of the pipeline.
__________________
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
12-21-21, 12:44 PM
-------
12-21-21, 12:50 PM
Klaatu..Verata..Necktie?
Join Date: May 2007
Location: SF Bay Area
Posts: 19,380
Bikes: Litespeed Ultimate, Ultegra; Canyon Endurace, 105; Battaglin MAX, Chorus; Bianchi 928 Veloce; Ritchey Road Logic, Dura Ace; Cannondale R500 RX100; Schwinn Circuit, Sante; Lotus Supreme, Dura Ace
Liked 13,226 Times
in
6,792 Posts
