Addiction LXXIX
#2552
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#2553
VFL For Life
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#2554
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#2555
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#2557
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#2559
Mostly Harmless
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#2560
serious cyclist
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#2561
serious cyclist
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#2562
Mostly Harmless
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Probably not.
#2563
Klaatu..Verata..Necktie?
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It's a little thingie that shows up in the "Overview". I think it started in the last few months. Since all my riding since 1995 is on the same roads, and my rides are stitched together from different bits depending on where I decide to turn, even though I'd ridden every single segment of the ride dozens to hundreds of times since signing up with Strava in 2014, this is only the second time I'd stitched these precise segments in this precise order.
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"Don't take life so serious-it ain't nohow permanent."
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"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
#2564
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#2565
serious cyclist
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#2566
Klaatu..Verata..Necktie?
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#2567
serious cyclist
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#2568
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Nothing. Anything that originated from mouse genes has to be laboriously re-engineered to humanize it so you don't have an immune response. A lot of the monoclonal antibody drugs originated as mouse antibodies. We clone out the genes and then take the sticky bits that bind the target, and build them into a human antibody gene framework.
EDIT: Remicade is one of those mAb products that isn't human or humanized. I'm surprised there are so many chimerics on the market, especially for chronic diseases. You'd think HAMA would be a problem (Human Anti Mouse Antibodies)
EDIT: Remicade is one of those mAb products that isn't human or humanized. I'm surprised there are so many chimerics on the market, especially for chronic diseases. You'd think HAMA would be a problem (Human Anti Mouse Antibodies)
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"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
Last edited by genejockey; 08-18-20 at 12:29 PM.
#2569
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#2570
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2 weeks later: "Hospitalizations are really high, but deaths haven't risen. Perhaps the virus isn't as fatal as it was?"
2 weeks later still: "Deaths are rising rapidly. So, no. The virus is still just as bad."
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"Don't take life so serious-it ain't nohow permanent."
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"Don't take life so serious-it ain't nohow permanent."
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#2571
VFL For Life
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Nothing. Anything that originated from mouse genes has to be laboriously re-engineered to humanize it so you don't have an immune response. A lot of the monoclonal antibody drugs originated as mouse antibodies. We clone out the genes and then take the sticky bits that bind the target, and build them into a human antibody gene framework.
#2572
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#2573
Klaatu..Verata..Necktie?
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#2574
Klaatu..Verata..Necktie?
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But to your original point, bats would be hell to make antibodies out of. Mice, at least, don't fly out when you open the cage to immunize them. And you can lift them by the tail and they can't bite you.
__________________
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
#2575
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