So to recap:
- unable to find a comfortable saddle
- "palms" go numb
Information that's important but missing:
- how long this bike has been owned
- is the OP riding regularly, and the problems have newly appeared, or have they just begin to pick up the miles?
Recommendation: Get a professional bike fit. Numb hands and saddle discomfort are indications of either a rider without sufficient miles, or a poor bike fit.
Asking BF for bike fit tips is not going to get you very useful help.