Addiction 2021.1
02-02-21, 10:22 AM
#4426
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02-02-21, 10:32 AM
#4427
Senior Member
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02-02-21, 10:33 AM
#4428
VFL For Life
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Not if doctors aren't testing genomes. #20thCenturyMedicine
02-02-21, 10:55 AM
#4429
Should Be More Popular
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We got over a foot, prolly about 14 or 15 inches. I tried to see if I could drive the Saturn on it but that was utter fail. I made the call of shame to our lawnmower guy who is VERY busy with snow removal but said he could plow the driveway tonight.
02-02-21, 11:05 AM
#4430
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02-02-21, 11:30 AM
#4431
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R.I.P. Hal Holbrook.
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02-02-21, 11:31 AM
#4432
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02-02-21, 11:33 AM
#4433
Senior Member
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02-02-21, 11:51 AM
#4434
Fat n slow
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We only ended up with about 6, which was a far cry from the 15 predicted.
One of my staff lives in Kingston and he got 2 feet+, another just south of Albany got 16.
Im satisfied.
One of my staff lives in Kingston and he got 2 feet+, another just south of Albany got 16.
Im satisfied.
02-02-21, 12:00 PM
#4435
VFL For Life
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02-02-21, 12:09 PM
#4436
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02-02-21, 12:33 PM
#4437
Mostly Harmless
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02-02-21, 12:34 PM
#4438
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02-02-21, 12:40 PM
#4439
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I did, however, get in a couple of hours of snow management today. Running a snow blower in deep snow is surprisingly physical. Some shoveling required. Also, snowshoed some trails for walks with Benson -- snow in the yard is up to her shoulders.
02-02-21, 12:53 PM
#4440
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02-02-21, 12:59 PM
#4441
Klaatu..Verata..Necktie?
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Here's the problem with that - the human genome is 4.5 Billion bases long. Each of us has two of them, so that's 9 billion bases. Find me the base(s), out of 9 billion, that make the difference. It's looking for a needle in a needle stack. It requires a LOT of genomes sequenced and categorized by disease, and also understanding that you can get to the same apparent disease via different sets of mutations.
Years ago, before the Human Genome Project had finished its first genome, my crazy ex-boss correctly observed that the information is not the genome itself, but rather the differences between them and what could be correlated to disease, so that all the people who invested in the HGS and other companies hoping to make money off the FIRST human genome sequence were likely to be disappointed. I believe they were, a bit.
Years ago, before the Human Genome Project had finished its first genome, my crazy ex-boss correctly observed that the information is not the genome itself, but rather the differences between them and what could be correlated to disease, so that all the people who invested in the HGS and other companies hoping to make money off the FIRST human genome sequence were likely to be disappointed. I believe they were, a bit.
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"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
02-02-21, 01:06 PM
#4442
cowboy, steel horse, etc
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Here's the problem with that - the human genome is 4.5 Billion bases long. Each of us has two of them, so that's 9 billion bases. Find me the base(s), out of 9 billion, that make the difference. It's looking for a needle in a needle stack. It requires a LOT of genomes sequenced and categorized by disease, and also understanding that you can get to the same apparent disease via different sets of mutations.
Years ago, before the Human Genome Project had finished its first genome, my crazy ex-boss correctly observed that the information is not the genome itself, but rather the differences between them and what could be correlated to disease, so that all the people who invested in the HGS and other companies hoping to make money off the FIRST human genome sequence were likely to be disappointed. I believe they were, a bit.
Years ago, before the Human Genome Project had finished its first genome, my crazy ex-boss correctly observed that the information is not the genome itself, but rather the differences between them and what could be correlated to disease, so that all the people who invested in the HGS and other companies hoping to make money off the FIRST human genome sequence were likely to be disappointed. I believe they were, a bit.
02-02-21, 01:08 PM
#4443
Klaatu..Verata..Necktie?
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Here's another way of looking at it: There are about 206,000 words in Moby Dick. The average word in English is about 5 letters long (4.7, but what's 0.3 letters among friends), so roughly 1 million letters. Imagine looking for a single misspelling in 9000 copies of Moby Dick. That's what trying to find a mutation in one human's genome is like.
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"Don't take life so serious-it ain't nohow permanent."
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02-02-21, 01:09 PM
#4444
Klaatu..Verata..Necktie?
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They're doing that. It's how we know when the new variants arrive, because they're serologically identical.
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"Don't take life so serious-it ain't nohow permanent."
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"Don't take life so serious-it ain't nohow permanent."
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02-02-21, 01:11 PM
#4445
Klaatu..Verata..Necktie?
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Also, I believe he was asking datlas about sequencing patient's genomes, not viral. But it was yesterday, and time keeps on slippin', slippin', slippin'....into the future.
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02-02-21, 01:21 PM
#4446
VFL For Life
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02-02-21, 01:26 PM
#4447
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Here's another way of looking at it: There are about 206,000 words in Moby Dick. The average word in English is about 5 letters long (4.7, but what's 0.3 letters among friends), so roughly 1 million letters. Imagine looking for a single misspelling in 9000 copies of Moby Dick. That's what trying to find a mutation in one human's genome is like.
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02-02-21, 01:42 PM
#4448
Klaatu..Verata..Necktie?
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You know this, but others may not: No one really does this at the individual level because everyone has genetic differences from others in the population, some of which are new mutations and some of which are inherited, but most of which have no detectable effects, even if you restrict the search to the 5-10% of the genome that is even transcribed! You can take a bunch of people with a clearly identified disease and look for genes where differences are statistically associates with disease within individuals, but it's a huge statistical undertaking and the answer is usually that one is dealing with a bunch of different mutations in a common set of genes. Even finding the causative genetic abnormality in a family with a hereditary disease can be difficult.
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02-02-21, 01:48 PM
#4449
Klaatu..Verata..Necktie?
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And, yeah, the silent mutations, noncoding region mutations, and within coding regions even conservative substitutions. All the stuff that piles up over a couple hundred thousand years since the last common ancestor of all humans...
Plus Neanderthal DNA.
It's like trying to find the one misspelling in the Library of Congress collection.
Plus Neanderthal DNA.
It's like trying to find the one misspelling in the Library of Congress collection.
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"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
"Don't take life so serious-it ain't nohow permanent."
"Everybody's gotta be somewhere." - Eccles
02-02-21, 01:55 PM
#4450
VFL For Life
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You can take a bunch of people with a clearly identified disease and look for genes where differences are statistically associates with disease within individuals, but it's a huge statistical undertaking and the answer is usually that one is dealing with a bunch of different mutations in a common set of genes.